Back

Volume 26 , Issue 2
March/April 2006
Pages 127-133

Comparison of Recombinant Human Platelet-Derived Growth Factor-BB Plus Beta Tricalcium Phosphate and a Collagen Membrane to Subepithelial Connective Tissue Grafting for the Treatment of Recession Defects: A Case Series

Michael K. McGuire, DDS / E. Todd Scheyer, DDS, MS

PMID: 16642901
DOI: 10.11607/prd.00.0680

When mixed with an osteoconductive scaffold, recombinant human platelet-derived growth factor (rhPDGF-BB), a potent wound-healing protein, has been shown to promote clinical attachment gain, radiographic bone fill, and regeneration of the periodontium. This human case series evaluated the clinical outcome of rhPDGF with beta tricalcium phosphate (b-TCP) and a collagen membrane in the treatment of recession-type defects. The control was the clinical gold standard for root coverage: the subepithelial connective tissue graft (CTG). Seven patients with recession defects ¡Ý 3 mm in contralateral quadrants of the maxilla, excluding molars, were treated in this series. Patients were followed postoperatively, and healing was evaluated at 8, 16, and 24 weeks, with recession depth as the primary outcome measure. This case series revealed a favorable tissue response to rhPDGF-BB + b-TCP and a collagen membrane and comparable clinical outcomes to CTG, warranting a controlled clinical trial of greater magnitude.
(Int J Periodontics Restorative Dent 2006;26:127¨C133.)

Full Text PDF File | Order Article

 

 

Adobe Acrobat Reader is required to view PDF files. This is a free program available from the Adobe web site.
Follow the download directions on the Adobe web site to get your copy of Adobe Acrobat Reader.